Site-specific dual functionalization of cysteine residue in peptides and proteins with 2-azidoacrylates

• المؤلفون الرئيسيون: Ariyasu, Shinya, Hayashi, Hirohito, Xing, Bengang, Chiba, Shunsuke
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Peptides and Proteins; Monomers
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/154857
• المؤسسة: Nanyang Technological University

Herein, we report use of 2-azidoacrylates to perform site-specific dual functionalization of the cysteine residue of peptides and bovine serum albumin (BSA), a native protein containing one free cysteine residue. The sulfhydryl group of the cysteine residue could be conjugated with 2-azidoacrylates...