Site-specific dual functionalization of cysteine residue in peptides and proteins with 2-azidoacrylates

• Main Authors: Ariyasu, Shinya, Hayashi, Hirohito, Xing, Bengang, Chiba, Shunsuke
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Chemistry; Peptides and Proteins; Monomers
• 在線閱讀: https://hdl.handle.net/10356/154857

Herein, we report use of 2-azidoacrylates to perform site-specific dual functionalization of the cysteine residue of peptides and bovine serum albumin (BSA), a native protein containing one free cysteine residue. The sulfhydryl group of the cysteine residue could be conjugated with 2-azidoacrylates...