Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza viruses

• Main Authors: Butler, Jeff, Hooper, Kathryn A., Petrie, Stephen, Lee, Raphael, Maurer-Stroh, Sebastian, Reh, Lucia, Guarnaccia, Teagan, Baas, Chantal, Xue, Lumin, Vitesnik, Sophie, Leang, Sook-Kwan, McVernon, Jodie, Kelso, Anne, Barr, Ian G., McCaw, James M., Bloom, Jesse D., Hurt, Aeron C.
• Other Authors: Perez, Daniel R.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: https://hdl.handle.net/10356/101749; http://hdl.handle.net/10220/19748
• Institution: Nanyang Technological University

Oseltamivir is relied upon worldwide as the drug of choice for the treatment of human influenza infection. Surveillance for oseltamivir resistance is routinely performed to ensure the ongoing efficacy of oseltamivir against circulating viruses. Since the emergence of the pandemic 2009 A(H1N1) influe...