Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses

Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M m...

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Bibliographic Details
Main Authors: Hurt, Aeron, Leang, Sook, Speers, David, Barr, Ian G., Maurer-Stroh, Sebastian
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/98120
http://hdl.handle.net/10220/13278
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Institution: Nanyang Technological University
Language: English