Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses

Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses

Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M m...

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Main Authors: Hurt, Aeron, Leang, Sook, Speers, David, Barr, Ian G., Maurer-Stroh, Sebastian
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/98120
http://hdl.handle.net/10220/13278
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-981202023-02-28T16:56:02Z Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses Hurt, Aeron Leang, Sook Speers, David Barr, Ian G. Maurer-Stroh, Sebastian School of Biological Sciences DRNTU::Science::Biological sciences Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity. Published Version 2013-08-29T08:35:48Z 2019-12-06T19:50:50Z 2013-08-29T08:35:48Z 2019-12-06T19:50:50Z 2012 2012 Journal Article Hurt, A., Leang, S., Speers, D., Barr, I.,& Maurer-Stroh, S. (2012). Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses. Emerging Infectious Diseases, 18(1). 1080-6040 https://hdl.handle.net/10356/98120 http://hdl.handle.net/10220/13278 10.3201/eid1801.111079 22260817 en Emerging infectious diseases © 2012 Public Domain. This paper was published in Emerging Infectious Diseases and is made available as an electronic reprint (preprint) with permission of Public Domain. The paper can be found at the following official DOI: [http://dx.doi.org/10.3201/eid1801.111079]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
spellingShingle DRNTU::Science::Biological sciences
Hurt, Aeron
Leang, Sook
Speers, David
Barr, Ian G.
Maurer-Stroh, Sebastian
Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
description Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Hurt, Aeron
Leang, Sook
Speers, David
Barr, Ian G.
Maurer-Stroh, Sebastian
format Article
author Hurt, Aeron
Leang, Sook
Speers, David
Barr, Ian G.
Maurer-Stroh, Sebastian
author_sort Hurt, Aeron
title Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
title_short Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
title_full Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
title_fullStr Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
title_full_unstemmed Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
title_sort mutations i117v and i117m and oseltamivir sensitivity of pandemic (h1n1) 2009 viruses
publishDate 2013
url https://hdl.handle.net/10356/98120
http://hdl.handle.net/10220/13278
_version_ 1759853115480211456

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