HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin

• Main Authors: Wu, Zhi Min, Zhou, Liying, Guo, Xin Dong, Jiang, Wei, Ling, Li, Qian, Yu, Luo, Kathy Qian, Zhang, Li Juan
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: https://hdl.handle.net/10356/102136; http://hdl.handle.net/10220/16821
• Institution: Nanyang Technological University

In this work, we designed and developed a two-stage delivery system composed of enteric capsule and cationic nanoparticles for oral delivery of insulin. The enteric capsule was coated with pH-sensitive hydroxypropyl methylcellulose phthalate (HP55), which could selectively release insulin from nanop...