A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation

• Main Authors: Feng, Chao, Zhou, Liying, Yu, Ting, Xu, Gang, Tian, Hong-Lei, Xu, Jin-Jie, Xu, Hong-Xi, Luo, Kathy Qian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/102141; http://hdl.handle.net/10220/16943
• Institution: Nanyang Technological University

Oblongifolin C (OC) was identified as a potent apoptosis inducer from an herbal plant, Garcinia yunnanensis, during our previous bioassay-guided drug screening. In this study, we investigated the signaling pathways through which OC activated apoptosis in HeLa cells. We also compared the IC50 values...