PPARβ interprets a chromatin signature of pluripotency to promote embryonic differentiation at gastrulation

• Main Authors: Rotman, Nicolas, Guex, Nicolas, Gouranton, Erwan, Wahli, Walter
• Other Authors: Knott, Jason Glenn
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/102143; http://hdl.handle.net/10220/18832
• Institution: Nanyang Technological University

Epigenetic post-transcriptional modifications of histone tails are thought to help in coordinating gene expression during development. An epigenetic signature is set in pluripotent cells and interpreted later at the onset of differentiation. In pluripotent cells, epigenetic marks normally associated...