Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

• Main Authors: Mistri, Tapan Kumar, Rahmani, Mehran, Woon, Chow Thai, Ng, Calista Keow Leng, Jauch, Ralf, Robson, Paul, Hutchins, Andrew Paul, Choo, Siew Hua
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2014
• 主題: DRNTU::Science::Biological sciences::Cytology
• 在線閱讀: https://hdl.handle.net/10356/102237; http://hdl.handle.net/10220/18922
• 機構: Nanyang Technological University

Transcription factors (TF) often bind in heterodimeric complexes with each TF recognizing a specific neighboring cis element in the regulatory region of the genome. Comprehension of this DNA motif grammar is opaque, yet recent developments have allowed the interrogation of genome-wide TF binding sit...