Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B

• Main Authors: Van Damme, Petra, Plasman, Kim, Vandemoortele, Giel, Jonckheere, Veronique, Maurer-Stroh, Sebastian, Gevaert, Kris
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/102506; http://hdl.handle.net/10220/24274
• Institution: Nanyang Technological University

Background Previous screening of the substrate repertoires and substrate specificity profiles of granzymes resulted in long substrate lists highly likely containing bystander substrates. Here, a recently developed degradomics technology that allows distinguishing efficiently from less efficiently cl...