Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization

• Main Authors: Choi, Bo-Hwa, Chattopadhaya, Souvik, Feng, Lin, Nguyen, Quoc Toan, Lim, Chuan Bian, Harikishore, Amaravadhi, Nanga, Ravi Prakash Reddy, Bharatham, Nagakumar, Zhao, Yan, Yoon, Ho Sup, Thanh, Le Nguyen, Liu, Xuewei
• Other Authors: Ko, Ben CB.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/102513; http://hdl.handle.net/10220/24263
• Institution: Nanyang Technological University

Microtubules are a highly validated target in cancer therapy. However, the clinical development of tubulin binding agents (TBA) has been hampered by toxicity and chemoresistance issues and has necessitated the search for new TBAs. Here, we report the identification of a novel cell permeable, tubulin...