Radical-mediated diamination of alkenes with phenylhydrazine and azodicarboxylates : highly diastereoselective synthesis of trans-diamines from cycloalkenes
Metal-free synthesis: Diamination of alkenes by using phenylhydrazine and azodicarboxylates could be achieved in a one-pot manner under very mild conditions (see scheme; Boc=tert-butoxycarbonyl). This process works with the assistance of acetic acid by means of a radical mechanism and displays a hig...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/102582 http://hdl.handle.net/10220/19226 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Metal-free synthesis: Diamination of alkenes by using phenylhydrazine and azodicarboxylates could be achieved in a one-pot manner under very mild conditions (see scheme; Boc=tert-butoxycarbonyl). This process works with the assistance of acetic acid by means of a radical mechanism and displays a high trans selectivity when cycloalkene substrates were used in the reaction. |
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