Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

• Main Authors: Pehere, Ashok D., Pietsch, Markus, Gütschow, Michael, Neilsen, Paul M., Pedersen, Daniel Sejer, Nguyen, Steven, Zvarec, Ondrej, Sykes, Matthew J., Callen, David F., Abell, Andrew D.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/102746; http://hdl.handle.net/10220/19119
• Institution: Nanyang Technological University

Peptide-derived protease inhibitors are an important class of compounds with the potential to treat a wide range of diseases. Herein, we describe the synthesis of a series of triazole-containing macrocyclic protease inhibitors pre-organized into a β-strand conformation and an evaluation of their act...