Design of short membrane selective antimicrobial peptides containing tryptophan and arginine residues for improved activity, salt-resistance, and biocompatibility

• Main Authors: Saravanan, Rathi, Li, Xiang, Lim, Kaiyang, Mohanram, Harini, Peng, Li, Mishra, Biswajit, Basu, Anindya, Lee, Jong-Min, Bhattacharjya, Surajit, Leong, Susanna Su Jan
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: https://hdl.handle.net/10356/102751; http://hdl.handle.net/10220/19188
• Institution: Nanyang Technological University

Antimicrobial peptides (AMPs) kill microbes by non-specific membrane permeabilization, making them ideal templates for designing novel peptide-based antibiotics that can combat multi-drug resistant pathogens. For maximum efficacy in vivo and in vitro, AMPs must be biocompatible, salt-tolerant and po...