Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols : synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones
2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)-mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ethyl acetate (20:1 v/v) as the reaction medium. The utility of the app...
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| Main Authors: | , , |
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| 格式: | Article |
| 語言: | English |
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2014
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| 在線閱讀: | https://hdl.handle.net/10356/102861 http://hdl.handle.net/10220/19218 |
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| 機構: | Nanyang Technological University |
| 語言: | English |