NMR characterization of the near native and unfolded states of the PTB domain of Dok1 : alternate conformations and residual clusters

• المؤلفون الرئيسيون: Gupta, Sebanti, Bhattacharjya, Surajit
• مؤلفون آخرون: Driscoll, Paul C.
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/102910; http://hdl.handle.net/10220/19074
• المؤسسة: Nanyang Technological University

Background: Phosphotyrosine binding (PTB) domains are critically involved in cellular signaling and diseases. PTB domains are categorized into three distinct structural classes namely IRS-like, Shc-like and Dab-like. All PTB domains consist of a core pleckstrin homology (PH) domain with additional...