NMR characterization of the near native and unfolded states of the PTB domain of Dok1 : alternate conformations and residual clusters

• Main Authors: Gupta, Sebanti, Bhattacharjya, Surajit
• Other Authors: Driscoll, Paul C.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/102910; http://hdl.handle.net/10220/19074
• Institution: Nanyang Technological University

Background: Phosphotyrosine binding (PTB) domains are critically involved in cellular signaling and diseases. PTB domains are categorized into three distinct structural classes namely IRS-like, Shc-like and Dab-like. All PTB domains consist of a core pleckstrin homology (PH) domain with additional...