PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3
The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and functional materials, owing to its unique properties such as electron-withdrawing character, metabolic stability, and lipophilicity. Described herein is the PhI(OAc)2-mediated radical trifluoromethyla...
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sg-ntu-dr.10356-1030362020-03-07T12:34:43Z PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 Wang, Yi-Feng Lonca, Geoffroy Hervé Chiba, Shunsuke School of Physical and Mathematical Sciences DRNTU::Science::Mathematics The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and functional materials, owing to its unique properties such as electron-withdrawing character, metabolic stability, and lipophilicity. Described herein is the PhI(OAc)2-mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 to efficiently generate α-trifluoromethyl azines. The resulting α-trifluoromethyl azines were successfully transformed to valuable fluorine-containing molecules such as α-trifluoromethyl ketones, β-trifluoromethyl amines, 5-fluoropyrazoles, and trifluoroethyl isoquinolines. 2014-04-07T02:22:54Z 2019-12-06T21:04:16Z 2014-04-07T02:22:54Z 2019-12-06T21:04:16Z 2014 2014 Journal Article Wang, Y.-F., Lonca, G. H., & Chiba, S. (2014). PhI(OAc)2-Mediated Radical Trifluoromethylation of Vinyl Azides with Me3SiCF3. Angewandte Chemie International Edition, 53(4), 1067-1071. 1433-7851 https://hdl.handle.net/10356/103036 http://hdl.handle.net/10220/19137 10.1002/anie.201307846 en Angewandte chemie international edition © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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DRNTU::Science::Mathematics Wang, Yi-Feng Lonca, Geoffroy Hervé Chiba, Shunsuke PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 |
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The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and functional materials, owing to its unique properties such as electron-withdrawing character, metabolic stability, and lipophilicity. Described herein is the PhI(OAc)2-mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 to efficiently generate α-trifluoromethyl azines. The resulting α-trifluoromethyl azines were successfully transformed to valuable fluorine-containing molecules such as α-trifluoromethyl ketones, β-trifluoromethyl amines, 5-fluoropyrazoles, and trifluoroethyl isoquinolines. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Wang, Yi-Feng Lonca, Geoffroy Hervé Chiba, Shunsuke |
format |
Article |
author |
Wang, Yi-Feng Lonca, Geoffroy Hervé Chiba, Shunsuke |
author_sort |
Wang, Yi-Feng |
title |
PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 |
title_short |
PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 |
title_full |
PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 |
title_fullStr |
PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 |
title_full_unstemmed |
PhI(OAc)2 mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 |
title_sort |
phi(oac)2 mediated radical trifluoromethylation of vinyl azides with me3sicf3 |
publishDate |
2014 |
url |
https://hdl.handle.net/10356/103036 http://hdl.handle.net/10220/19137 |
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1681035648009502720 |