Significance of the d-Serine-deaminase and d-Serine metabolism of staphylococcus saprophyticus for virulence

• Main Authors: Kline, Kimberly A., Korte-Berwanger, Miriam, Sakinc, Türkan, Nielsen, Hailyn V., Hultgren, Scott, Gatermann, Sören G.
• Other Authors: Camilli, A.
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/103049; http://hdl.handle.net/10220/25761
• Institution: Nanyang Technological University

Staphylococcus saprophyticus is the only species of Staphylococcus that is typically uropathogenic and possesses a gene coding for a D-serine-deaminase (DsdA). As D-serine is prevalent in urine and toxic or bacteriostatic to many bacteria, it is not surprising that the D-serine-deaminase gene is fou...