Novel acetamide indirectly targets mycobacterial transporter MmpL3 by proton motive force disruption

• Main Authors: Shetty, Annanya, Xu, Zhujun, Lakshmanan, Umayal, Hill, Jeffrey, Choong, Meng Ling, Chng, Shu-Sin, Yamada, Yoshiyuki, Poulsen, Anders, Dick, Thomas, Gengenbacher, Martin
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Engineering::Environmental engineering; Mycobacterium Tuberculosis; Cell Envelope Stress
• Online Access: https://hdl.handle.net/10356/103330; http://hdl.handle.net/10220/47321
• Institution: Nanyang Technological University

To identify novel inhibitors of Mycobacterium tuberculosis cell envelope biosynthesis, we employed a two-step approach. First, we screened the diverse synthetic small molecule 71,544-compound Enamine library for growth inhibitors using the non-pathogenic surrogate Mycobacterium bovis BCG as screenin...