Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes

Alpha-1 antitrypsin (AAT) deficiency remains an underrecognized genetic disease with predominantly pulmonary and hepatic manifestations. AAT is derived primarily from hepatocytes; however, macrophages and neutrophils are secondary sources. As the natural physiological inhibitor of several proteases,...

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Bibliographic Details
Main Authors: Chotirmall, Sanjay Haresh, Al-Alawi, Mazen, McEnery, Thomas, McElvaney, Noel Gerard
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/103341
http://hdl.handle.net/10220/25999
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Institution: Nanyang Technological University
Language: English