Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes
Alpha-1 antitrypsin (AAT) deficiency remains an underrecognized genetic disease with predominantly pulmonary and hepatic manifestations. AAT is derived primarily from hepatocytes; however, macrophages and neutrophils are secondary sources. As the natural physiological inhibitor of several proteases,...
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Main Authors: | Chotirmall, Sanjay Haresh, Al-Alawi, Mazen, McEnery, Thomas, McElvaney, Noel Gerard |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2015
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/103341 http://hdl.handle.net/10220/25999 |
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Institution: | Nanyang Technological University |
Language: | English |
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