Antibody treatment against angiopoietin-like 4 reduces pulmonary edema and injury in secondary pneumococcal pneumonia

• Main Authors: Li, Liang, Foo, Benjamin Jie Wei, Kwok, Ka Wai, Sakamoto, Noriho, Mukae, Hiroshi, Izumikawa, Koichi, Mandard, Stéphane, Quenot, Jean-Pierre, Lagrost, Laurent, Teh, Wooi Keong, Zhu, Pengcheng, Choi, Hyungwon, Buist, Martin Lindsay, Seet, Ju Ee, Yang, Liang, He, Fang, Tan, Nguan Soon, Kohli, Gurjeet Singh, Chow, Vincent Tak Kwong
• Other Authors: Pirofski, Liise-anne
• Format: Article
• Language: English
• Published: 2019
• Subjects: Secondary Bacterial Pneumonia; Science::Biological sciences; ANGPTL4
• Online Access: https://hdl.handle.net/10356/103415; http://hdl.handle.net/10220/49493
• Institution: Nanyang Technological University

Secondary bacterial lung infection by Streptococcus pneumoniae (S.pneumoniae) poses a serious health concern, especially in developing countries. We posit that the emergence of multiantibiotic-resistant strains will jeopardize current treatments in these regions. Deaths arising from secondary infect...