Heme prevents amyloid beta peptide aggregation through hydrophobic interaction based on molecular dynamics simulation

• Main Authors: Zhao, Li Na, Mu, Yuguang, Chew, Lock Yue
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Biophysics
• Online Access: https://hdl.handle.net/10356/103444; http://hdl.handle.net/10220/24524
• Institution: Nanyang Technological University

Heme, which is abundant in hemoglobin and many other hemoproteins, is known to play an important role in electron transfer, oxygen transport, regulation of gene expression, and many other biological functions. With the belief that the aggregation of Aβ peptides forming higher order oligomers is one...