Unconventional Bifunctional Lewis-Brønsted Acid Activation Mode in Bicyclic Guanidine-Catalyzed Conjugate Addition Reactions

• Main Authors: Cho, Bokun, Wong, Ming Wah
• Other Authors: Energy Research Institute @ NTU (ERI@N)
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/103510; http://hdl.handle.net/10220/38773
• Institution: Nanyang Technological University

DFT calculations have demonstrated that the unconventional bifunctional Brønsted-Lewis acid activation mode is generally applicable to a range of nucleophilic conjugate additions catalyzed by bicyclic guanidine catalysts. It competes readily with the conventional bifunctional Brønsted acid mode of a...