Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

• Main Authors: Hor, Jin Hui, Soh, Eunice Shi-Yi, Tan, Li Yi, Lim, Valerie Jing Wen, Winanto, Ho, Beatrice Xuan, Fan, Yong, Soh, Boon-Seng, Ng, Shi-Yan, Munirah Mohamad Santosa
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Cell Cycle Inhibitors; Spinal Muscular Atrophy
• Online Access: https://hdl.handle.net/10356/103564; http://hdl.handle.net/10220/47342
• Institution: Nanyang Technological University

Spinal Muscular Atrophy (SMA) is caused by genetic mutations in the SMN1 gene, resulting in drastically reduced levels of Survival of Motor Neuron (SMN) protein. Although SMN is ubiquitously expressed, spinal motor neurons are one of the most affected cell types. Previous studies have identified pat...