The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass

The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass

Background: The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods: The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using...

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Bibliographic Details
Main Authors: Jahan, Mahabuba, Johnström, Peter, Selvaraju, Ram K., Svedberg, Marie, Winzell, Maria Sörhede, Bernström, Jenny, Kingston, Lee, Schou, Magnus, Jia, Zhisheng, Skrtic, Stanko, Johansson, Lars, Korsgren, Olle, Farde, Lars, Halldin, Christer, Eriksson, Olof
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2019
Subjects:
DRNTU::Science::Medicine
Beta Cell Imaging
G-Protein-Coupled Receptor 44 (GPR44)
Online Access:https://hdl.handle.net/10356/103580
http://hdl.handle.net/10220/48602
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/103580
http://hdl.handle.net/10220/48602

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