Development of metal complexes for specific targeting G-quadruplexes and the application studies

• Main Author: He, Lei
• Other Authors: Shao Fangwei
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Chemistry::Inorganic chemistry; DRNTU::Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/103674; http://hdl.handle.net/10220/47435
• Institution: Nanyang Technological University

Guanine quadruplexes (GQ) with non-canonical four-stranded structures play a plethora of vital biological roles and technological functionalities. Metal complexes with extensive aromatic ligands could bind GQ with high specificity and possess unique features in biomedicine, biotechnology and nanotec...