Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways

• Main Authors: Gonzales, Kevin Andrew Uy, Liang, Hongqing, Lim, Yee-Siang, Chan, Yun-Shen, Yeo, Jia-Chi, Tan, Cheng-Peow, Gao, Bin, Le, Beilin, Tan, Zi-Ying, Low, Kok-Yao, Liou, Yih-Cherng, Bard, Frederic, Ng, Huck-Hui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/103694; http://hdl.handle.net/10220/38785
• Institution: Nanyang Technological University

During differentiation, human embryonic stem cells (hESCs) shut down the regulatory network conferring pluripotency in a process we designated pluripotent state dissolution (PSD). In a high-throughput RNAi screen using an inclusive set of differentiation conditions, we identify centrally important a...