From conventional to unconventional : glycosylation on semi-protected donors and syntheses towards natural products
The specific stereo-configuration at each anomeric linkage and the diversity in branching burdens the synthesis of glycans. In this thesis, we introduce a widely applicable open-glycosylation method for the boron-assisted construction of various glycosidic connections. Furthermore, we manifested the...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2019
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| Online Access: | https://hdl.handle.net/10356/103721 http://hdl.handle.net/10220/47430 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The specific stereo-configuration at each anomeric linkage and the diversity in branching burdens the synthesis of glycans. In this thesis, we introduce a widely applicable open-glycosylation method for the boron-assisted construction of various glycosidic connections. Furthermore, we manifested the practicality of this approach in a one-pot assembly of a model trisaccharide. Lastly, we conceptualized a divergent synthetic route for the syntheses of natural products and made significant steps towards their completion. |
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