A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides

A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides

A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.

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Main Authors: Wu, Xiaojin, See, Jessica Wei Ting, Xu, Kai, Hirao, Hajime, Roger, Julien, Hierso, Jean-Cyrille, Zhou, Jianrong Steve
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry
Online Access:https://hdl.handle.net/10356/103739
http://hdl.handle.net/10220/24565
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1037392020-03-07T12:31:31Z A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides Wu, Xiaojin See, Jessica Wei Ting Xu, Kai Hirao, Hajime Roger, Julien Hierso, Jean-Cyrille Zhou, Jianrong Steve School of Physical and Mathematical Sciences DRNTU::Science::Chemistry A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved. 2014-12-30T03:35:19Z 2019-12-06T21:19:11Z 2014-12-30T03:35:19Z 2019-12-06T21:19:11Z 2014 2014 Journal Article Wu, X., See, J. W. T., Xu, K., Hirao, H., Roger, J., Hierso, J.-C., et al. (2014). A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides. Angewandte chemie international edition, 53(49), 13573-13577. 1433-7851 https://hdl.handle.net/10356/103739 http://hdl.handle.net/10220/24565 10.1002/anie.201408355 en Angewandte chemie international edition © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Chemistry
spellingShingle DRNTU::Science::Chemistry
Wu, Xiaojin
See, Jessica Wei Ting
Xu, Kai
Hirao, Hajime
Roger, Julien
Hierso, Jean-Cyrille
Zhou, Jianrong Steve
A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
description A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Wu, Xiaojin
See, Jessica Wei Ting
Xu, Kai
Hirao, Hajime
Roger, Julien
Hierso, Jean-Cyrille
Zhou, Jianrong Steve
format Article
author Wu, Xiaojin
See, Jessica Wei Ting
Xu, Kai
Hirao, Hajime
Roger, Julien
Hierso, Jean-Cyrille
Zhou, Jianrong Steve
author_sort Wu, Xiaojin
title A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
title_short A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
title_full A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
title_fullStr A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
title_full_unstemmed A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
title_sort general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides
publishDate 2014
url https://hdl.handle.net/10356/103739
http://hdl.handle.net/10220/24565
_version_ 1681033937537728512

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