A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides

• Main Authors: Wu, Xiaojin, See, Jessica Wei Ting, Xu, Kai, Hirao, Hajime, Roger, Julien, Hierso, Jean-Cyrille, Zhou, Jianrong Steve
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/103739; http://hdl.handle.net/10220/24565
• Institution: Nanyang Technological University

A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.