Recent advance of biological molecular imaging based on lanthanide-doped upconversion-luminescent nanomaterials
Lanthanide-doped upconversion-luminescent nanoparticles (UCNPs), which can be excited by near-infrared (NIR) laser irradiation to emit multiplex light, have been proven to be very useful for in vitro and in vivo molecular imaging studies. In comparison with the conventionally used down-conversion...
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/103766 http://hdl.handle.net/10220/19289 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Lanthanide-doped upconversion-luminescent nanoparticles (UCNPs), which can
be excited by near-infrared (NIR) laser irradiation to emit multiplex light, have been
proven to be very useful for in vitro and in vivo molecular imaging studies. In comparison
with the conventionally used down-conversion fluorescence imaging strategies, the NIR
light excited luminescence of UCNPs displays high photostability, low cytotoxicity, little
background auto-fluorescence, which allows for deep tissue penetration, making them
attractive as contrast agents for biomedical imaging applications. In this review, we will
mainly focus on the latest development of a new type of lanthanide-doped UCNP material
and its main applications for in vitro and in vivo molecular imaging and we will also
discuss the challenges and future perspectives. |
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