Defects in β-cell Ca2+ dynamics in age-induced diabetes

• Main Authors: Li, Luosheng, Trifunovic, Aleksandra, Köhler, Martin, Wang, Yixin, Petrovic Berglund, Jelena, Illies, Christopher, Juntti-Berggren, Lisa, Larsson, Nils-Göran, Berggren, Per-Olof
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/103782; http://hdl.handle.net/10220/24587
• Institution: Nanyang Technological University

Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca2+ dynamics in mouse β-cells. We show that these chan...