A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-Dichlorobenzamil on the digestive vacuole of plasmodium falciparum

• Main Authors: Lee, Yan Quan, Goh, Amanda S. P., Ch'ng, Jun-Hong, Nosten, François H., Presier, Peter Rainer, Pervaiz, Shazib, Yadav, Sanjiv Kumar, Tan, Kevin S. W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Microbial ecology
• Online Access: https://hdl.handle.net/10356/103805; http://hdl.handle.net/10220/25095
• Institution: Nanyang Technological University

Plasmodium falciparum is the etiological agent of malignant malaria and has been shown to exhibit features resembling programmed cell death. This is triggered upon treatment with low micromolar doses of chloroquine or other lysosomotrophic compounds and is associated with leakage of the digestive va...