A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-Dichlorobenzamil on the digestive vacuole of plasmodium falciparum

Plasmodium falciparum is the etiological agent of malignant malaria and has been shown to exhibit features resembling programmed cell death. This is triggered upon treatment with low micromolar doses of chloroquine or other lysosomotrophic compounds and is associated with leakage of the digestive va...

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Main Authors: Lee, Yan Quan, Goh, Amanda S. P., Ch'ng, Jun-Hong, Nosten, François H., Presier, Peter Rainer, Pervaiz, Shazib, Yadav, Sanjiv Kumar, Tan, Kevin S. W.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/103805
http://hdl.handle.net/10220/25095
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Institution: Nanyang Technological University
Language: English