Competing targets of microRNA-608 affect anxiety and hypertension

• Main Authors: Geifman-Shochat, Susana, Hanin, Geula, Shenhar-Tsarfaty, Shani, Yayon, Nadav, Hoe, Yau Yin, Bennett, Estelle R., Sklan, Ella H., Rao, Dabeeru. C., Rankinen, Tuomo, Bouchard, Claude, Shifman, Sagiv, Greenberg, David S., Soreq, Hermona
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/103870; http://hdl.handle.net/10220/19851
• Institution: Nanyang Technological University

MicroRNAs (miRNAs) can repress multiple targets, but how a single de-balanced interaction affects others remained unclear. We found that changing a single miRNA–target interaction can simultaneously affect multiple other miRNA–target interactions and modify physiological phenotype. We show that miR-...