Chemical synthesis of circular proteins

• Main Authors: Tam, James P., Wong, Clarence T. T.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103952; http://hdl.handle.net/10220/17091
• Institution: Nanyang Technological University

Circular proteins, once thought to be rare, are now commonly found in plants. Their chemical synthesis, once thought to be difficult, is now readily achievable. The enabling methodology is largely due to the advances in entropic chemical ligation to overcome the entropy barrier in coupling the N- an...