Immobilization and intracellular delivery of circular proteins by modifying a genetically incorporated unnatural amino acid

Backbone-cyclic proteins are of great scientific and therapeutic interest owing to their higher stability over their linear counterparts. Modification of such cyclic proteins at a selected site would further enhance their versatility. Here we report a chemoenzymatic strategy to engineer site-selecti...

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Bibliographic Details
Main Authors: Bi, Xiaobao, Yin, Juan, Hemu, Xinya, Rao, Chang, Tam, James P., Liu, Chuan-Fa
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/143952
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Institution: Nanyang Technological University
Language: English