Immobilization and intracellular delivery of circular proteins by modifying a genetically incorporated unnatural amino acid

• المؤلفون الرئيسيون: Bi, Xiaobao, Yin, Juan, Hemu, Xinya, Rao, Chang, Tam, James P., Liu, Chuan-Fa
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences::Biochemistry; Peptides and Proteins; Monomers
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/143952

Backbone-cyclic proteins are of great scientific and therapeutic interest owing to their higher stability over their linear counterparts. Modification of such cyclic proteins at a selected site would further enhance their versatility. Here we report a chemoenzymatic strategy to engineer site-selecti...