Inhibition of HBV-induced angiogenesis by ibuprofen : role of HBx

• Main Authors: Zhang, Jianhua, Chen, William Wei Ning
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/103984; http://hdl.handle.net/10220/17190
• Institution: Nanyang Technological University

Chronic hepatitis B virus (HBV) carriers may develop hepatocellular carcinoma (HCC) by a wide range of mechanisms including angiogenesis. We show that HBV replication induces the expression of angiogenic proteins interleukin 6 (IL6) and cyclooxygenase-2 (Cox2). Interestingly, ibuprofen (a Cox2 inhib...