R-Loops in proliferating cells but not in the brain : implications for AOA2 and other autosomal recessive ataxias

• Main Authors: Yeo, Abrey J., Becherel, Olivier J., Luff, John E., Cullen, Jason K., Wongsurawat, Thidathip, Jenjaroenpoon, Piroon, Kuznetsov, Vladimir A., McKinnon, Peter J., Lavin, Martin F.
• Other Authors: Gueven, Nuri
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/104114; http://hdl.handle.net/10220/19519
• Institution: Nanyang Technological University

Disruption of the Setx gene, defective in ataxia oculomotor apraxia type 2 (AOA2) leads to the accumulation of DNA/RNA hybrids (R-loops), failure of meiotic recombination and infertility in mice. We report here the presence of R-loops in the testes from other autosomal recessive ataxia mouse models,...