Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis

• Main Authors: Mo, Junming, Yang, Ruojie, Chen, Xingkuan, Tiwari, Bhoopendra, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/104160; http://hdl.handle.net/10220/19446
• Institution: Nanyang Technological University

A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester interme...