Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis

Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis

A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester interme...

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Main Authors: Mo, Junming, Yang, Ruojie, Chen, Xingkuan, Tiwari, Bhoopendra, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry::Organic chemistry
Online Access:https://hdl.handle.net/10356/104160
http://hdl.handle.net/10220/19446
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1041602020-03-07T12:34:57Z Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis Mo, Junming Yang, Ruojie Chen, Xingkuan Tiwari, Bhoopendra Chi, Robin Yonggui School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones. 2014-05-26T02:21:10Z 2019-12-06T21:27:36Z 2014-05-26T02:21:10Z 2019-12-06T21:27:36Z 2012 2012 Journal Article Mo, J., Yang, R., Chen, X., Tiwari, B., & Chi, Y. R. (2013). Direct α-Functionalization of Simple Aldehydes via Oxidative N-Heterocyclic Carbene Catalysis. Organic Letters, 15(1), 50–53. 1523-7060 https://hdl.handle.net/10356/104160 http://hdl.handle.net/10220/19446 10.1021/ol303035r 173629 en Organic letters © 2012 American Chemical Society.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry
spellingShingle DRNTU::Science::Chemistry::Organic chemistry
Mo, Junming
Yang, Ruojie
Chen, Xingkuan
Tiwari, Bhoopendra
Chi, Robin Yonggui
Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
description A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Mo, Junming
Yang, Ruojie
Chen, Xingkuan
Tiwari, Bhoopendra
Chi, Robin Yonggui
format Article
author Mo, Junming
Yang, Ruojie
Chen, Xingkuan
Tiwari, Bhoopendra
Chi, Robin Yonggui
author_sort Mo, Junming
title Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
title_short Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
title_full Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
title_fullStr Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
title_full_unstemmed Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
title_sort direct α-functionalization of simple aldehydes via oxidative n-heterocyclic carbene catalysis
publishDate 2014
url https://hdl.handle.net/10356/104160
http://hdl.handle.net/10220/19446
_version_ 1681036174267777024

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