Identification of cis-acting elements and splicing factors involved in the regulation of BIM pre-mRNA splicing

• Main Authors: Juan, Wen Chun, Roca, Xavier, Ong, S. Tiong
• Other Authors: Buratti, Emanuele
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104198; http://hdl.handle.net/10220/19565
• Institution: Nanyang Technological University

Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis b...