DNA-templated silver nanoclusters for multiplexed fluorescent DNA detection

• Main Authors: Zhu, Changfeng, Zhang, Lei, Tan, Chaoliang, Yang, Jian, Chen, Bo, Wang, Lianhui, Zhang, Hua, Zhang, Ying
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/104208; http://hdl.handle.net/10220/24683
• Institution: Nanyang Technological University

Novel label-free/conjugation-free molecular beacons are designed based on DNA templated-silver nanoclusters for multiplexed DNA detection. The assay is implemented in solution, which makes it easy for the in-situ and real-time analysis. This study demonstrates a new method for multiplexd detection of biological molecules by using fluorescent Ag nanocluster-based molecular beacon probes.