Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release

• Main Authors: Li, Xin, Zhu, Pengcheng, Tan, Nguan Soon, Ågren, Hans, Zhao, Yanli, Jana, Avijit, Nguyen, Kim Truc
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences; DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/104219; http://hdl.handle.net/10220/19427
• Institution: Nanyang Technological University

An organic nanoparticle-based drug delivery system with high drug loading efficacy (79 wt %) was developed using a perylene-derived photoremovable protecting group, namely, perylene-3,4,9,10-tetrayltetramethanol (Pe(OH)4). The anticancer drug chlorambucil was protected by coupling with Pe(OH)4 to fo...