Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release
An organic nanoparticle-based drug delivery system with high drug loading efficacy (79 wt %) was developed using a perylene-derived photoremovable protecting group, namely, perylene-3,4,9,10-tetrayltetramethanol (Pe(OH)4). The anticancer drug chlorambucil was protected by coupling with Pe(OH)4 to fo...
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sg-ntu-dr.10356-1042192020-06-01T10:21:15Z Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release Li, Xin Zhu, Pengcheng Tan, Nguan Soon Ågren, Hans Zhao, Yanli Jana, Avijit Nguyen, Kim Truc School of Materials Science & Engineering School of Biological Sciences School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences DRNTU::Science::Chemistry::Organic chemistry An organic nanoparticle-based drug delivery system with high drug loading efficacy (79 wt %) was developed using a perylene-derived photoremovable protecting group, namely, perylene-3,4,9,10-tetrayltetramethanol (Pe(OH)4). The anticancer drug chlorambucil was protected by coupling with Pe(OH)4 to form photocaged nanoparticles (Pe(Cbl)4). The photorelease mechanism of chlorambucil from the Pe(Cbl)4 conjugate was investigated experimentally by high-resolution mass spectrometry and theoretically by density functional theory calculations. The Pe(Cbl)4 nanoparticles perform four important roles: (i) a nanocarrier for drug delivery, (ii) a phototrigger for drug release, (iii) a fluorescent chromophore for cell imaging, and (iv) a photoswitchable fluorophore for real-time monitoring of drug release. Tunable emission of the perylene-derived nanoparticles was demonstrated by comparing the emission properties of the Pe(OH)4 and Pe(Cbl)4 nanoparticles with perylene-3-ylmethanol. These nanoparticles were subsequently employed in cell imaging for investigating their intracellular localization. Furthermore, the in vivo toxicity of the Pe(OH)4 nanoparticles was investigated using the mouse model. Histological tissue analysis of five major organs, i.e., heart, kidney, spleen, liver, and lung, indicates that the nanoparticles did not show any obvious damage to these major organs under the experimental conditions. The current research presents a successful example of integrating multiple functions into single-component organic nanoparticles for drug delivery. 2014-05-22T08:17:34Z 2019-12-06T21:28:34Z 2014-05-22T08:17:34Z 2019-12-06T21:28:34Z 2014 2014 Journal Article Jana, A., Nguyen, K. T., Li, X., Zhu, P., Tan, N. S., Ågren, H., et al. (2014). Perylene-Derived Single-Component Organic Nanoparticles with Tunable Emission: Efficient Anticancer Drug Carriers with Real-Time Monitoring of Drug Release. ACS Nano, in press. 1936-0851 https://hdl.handle.net/10356/104219 http://hdl.handle.net/10220/19427 10.1021/nn501073x 179633 en ACS Nano © 2014 American Chemical Society. |
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DRNTU::Science::Biological sciences DRNTU::Science::Chemistry::Organic chemistry Li, Xin Zhu, Pengcheng Tan, Nguan Soon Ågren, Hans Zhao, Yanli Jana, Avijit Nguyen, Kim Truc Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release |
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An organic nanoparticle-based drug delivery system with high drug loading efficacy (79 wt %) was developed using a perylene-derived photoremovable protecting group, namely, perylene-3,4,9,10-tetrayltetramethanol (Pe(OH)4). The anticancer drug chlorambucil was protected by coupling with Pe(OH)4 to form photocaged nanoparticles (Pe(Cbl)4). The photorelease mechanism of chlorambucil from the Pe(Cbl)4 conjugate was investigated experimentally by high-resolution mass spectrometry and theoretically by density functional theory calculations. The Pe(Cbl)4 nanoparticles perform four important roles: (i) a nanocarrier for drug delivery, (ii) a phototrigger for drug release, (iii) a fluorescent chromophore for cell imaging, and (iv) a photoswitchable fluorophore for real-time monitoring of drug release. Tunable emission of the perylene-derived nanoparticles was demonstrated by comparing the emission properties of the Pe(OH)4 and Pe(Cbl)4 nanoparticles with perylene-3-ylmethanol. These nanoparticles were subsequently employed in cell imaging for investigating their intracellular localization. Furthermore, the in vivo toxicity of the Pe(OH)4 nanoparticles was investigated using the mouse model. Histological tissue analysis of five major organs, i.e., heart, kidney, spleen, liver, and lung, indicates that the nanoparticles did not show any obvious damage to these major organs under the experimental conditions. The current research presents a successful example of integrating multiple functions into single-component organic nanoparticles for drug delivery. |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Li, Xin Zhu, Pengcheng Tan, Nguan Soon Ågren, Hans Zhao, Yanli Jana, Avijit Nguyen, Kim Truc |
format |
Article |
author |
Li, Xin Zhu, Pengcheng Tan, Nguan Soon Ågren, Hans Zhao, Yanli Jana, Avijit Nguyen, Kim Truc |
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Li, Xin |
title |
Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release |
title_short |
Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release |
title_full |
Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release |
title_fullStr |
Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release |
title_full_unstemmed |
Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release |
title_sort |
perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time monitoring of drug release |
publishDate |
2014 |
url |
https://hdl.handle.net/10356/104219 http://hdl.handle.net/10220/19427 |
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1681057814927114240 |