Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-c kinase 1 (RACK1)

• Main Authors: Cornvik, Tobias Carl, Ruedl, Christiane, Feng, Chen, Li, Yan Feng, Yau, Yin Hoe, Lee, Hui-Shan, Tang, Xiao-Yan, Xue, Zhi-Hong, Zhou, Yi-Chao, Lim, Wei-Min, Shochat, Susana Geifman, Tan, Suet Mien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104232; http://hdl.handle.net/10220/16987
• Institution: Nanyang Technological University

Integrins are heterodimeric type I membrane cell adhesion molecules that are involved in many biological processes. Integrins are bidirectional signal transducers because their cytoplasmic tails are docking sites for cytoskeletal and signaling molecules. Kindlins are cytoplasmic molecules that media...