DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins

DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins

DNA methylation is essential in mammalian development. We have hypothesized that methylation differences induced by trisomy 21 (T21) contribute to the phenotypic characteristics and heterogeneity in Down syndrome (DS). In order to determine the methylation differences in T21 without interference of...

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Bibliographic Details
Main Authors: Sailani, M. Reza, Santoni, Federico A., Letourneau, Audrey, Borel, Christelle, Makrythanasis, Periklis, Hibaoui, Youssef, Popadin, Konstantin, Bonilla, Ximena, Guipponi, Michel, Gehrig, Corinne, Vannier, Anne, Carre-Pigeon, Frederique, Feki, Anis, Nizetic, Dean, Antonarakis, Stylianos E.
Other Authors: El-Maarri, Osman
Format: Article
Language:English
Published: 2015
Subjects:
Homeobox
Fibroblasts
Epigenetics
Induced pluripotent stem cells
Chromosome 21
Morphogenesis
Twins
DNA methylation
Online Access:https://hdl.handle.net/10356/104323
http://hdl.handle.net/10220/38815
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/104323
http://hdl.handle.net/10220/38815

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