DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins

• Main Authors: Sailani, M. Reza, Santoni, Federico A., Letourneau, Audrey, Borel, Christelle, Makrythanasis, Periklis, Hibaoui, Youssef, Popadin, Konstantin, Bonilla, Ximena, Guipponi, Michel, Gehrig, Corinne, Vannier, Anne, Carre-Pigeon, Frederique, Feki, Anis, Nizetic, Dean, Antonarakis, Stylianos E.
• Other Authors: El-Maarri, Osman
• Format: Article
• Language: English
• Published: 2015
• Subjects: Homeobox; Fibroblasts; Epigenetics; Induced pluripotent stem cells; Chromosome 21; Morphogenesis; Twins; DNA methylation
• Online Access: https://hdl.handle.net/10356/104323; http://hdl.handle.net/10220/38815
• Institution: Nanyang Technological University

DNA methylation is essential in mammalian development. We have hypothesized that methylation differences induced by trisomy 21 (T21) contribute to the phenotypic characteristics and heterogeneity in Down syndrome (DS). In order to determine the methylation differences in T21 without interference of...